Peel the garlic, leaving the cloves whole. Lightly smash the cloves with the back of your knife to help release the aroma but do not chop it.
Add the garlic and olive oil to a large skillet and set over low heat. Gently cook until the garlic is fragrant, pale golden and soft, being careful not to brown the garlic (5 minutes or so). The key to this sauce is to cook the garlic very slowly at a low temperature, turning the harsh garlic flavor into a sweet one. Add the red pepper flakes if using and cook for 30 seconds or so.
Add the white wine and let cook for another two minutes until the alcohol has burned off.
Add the canned tomatoes and salt and bring up to a simmer. Gently simmer the aglione sauce, breaking up the tomatoes with the back of your spoon from time to time for about 1 hour. The agione sauce should reduce with the cooking time, resulting in a nice and thick sauce. If for any reason the aglione sauce becomes overly thick and starts sticking to the bottom of the pan, add ¼ cup of water and continue cooking, uncovered.
Season for salt and with an immersion blender, blend until smooth. You can also do this with a blender after the aglione sauce has cooled down.
Cook the pici pasta in a very large pot of salted, boiling water. Save about ½ cup of starchy water before draining.
Drain well and dress with the aglione sauce. If you find the pici all’aglione too dry, add a bit of the pasta cooking water to help loosen things lol up.